Fresh analysis indicates that individuals who stop using new slimming jabs like Wegovy and Mounjaro can put back on lost weight at a significantly accelerated pace than those who end traditional lifestyle programs.
Published data in a major health publication demonstrates that while overweight individuals can lose substantial amounts of their body weight while undergoing treatment, the weight returns at an average rate of 0.8 kg per month upon discontinuation.
"People using such treatments should be aware of the potential of fast rebound weight gain when the medication ends," warns lead investigator Dr. Susan Jebb.
Such speed of regain implies a reversion to starting mass in about 18 months.
Analyzing Approaches
The study, which looked at dozens of trials involving over 9,000 of participants, compared the results of GLP-1 agonists with other pills.
Researchers emphasize that people who shed pounds through dieting typically experience a less rapid creep back—perhaps 100 grams monthly—once they finish.
The Reason for the Quick Rebound
Experts suggest the mode of action of the jabs explains the accelerated rebound.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which controls feelings of fullness.
"Artificially providing GLP-1 levels far above than the body's typical production may cause the system to generate a reduced amount of its endogenous GLP-1, and may also lessen sensitivity to its effects," noted Dr. Adam Collins, a nutrition expert.
"Stopping of this medication means hunger is uncontrolled, making binge eating much more probable."
A Chronic Disease?
Medical guidelines recommend the jabs for individuals with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
Many experts say that, due to the high risk of weight regain, the treatment might need to be ongoing.
This perspective is echoed by pharmaceutical companies, who say that the results "highlight the persistent character of excess weight," similar to managing diseases like diabetes.
User Testimonies
People who have stopped the medication describe a powerful return of appetite.
"It felt as if something flipping and you become starving," described a patient.
The struggle is worsened if individuals have not adopted lasting dietary or behavioural changes during treatment.
Growing Interest
Recent estimates indicate that a significant number of people in the UK have used weight-loss jabs in the past year, with interest being substantial.
- Adoption is higher among women than males.
- The middle-aged age group shows the highest usage rates.
- A large proportion obtain the medications through private prescriptions rather than public health services.
Ultimately, researchers stress that while these medications are powerful tools for shedding pounds, they are not a permanent cure and long-term success likely depends on integrated behavioural changes.
